MSH6, Clone 44

Mouse Monoclonal. Ready-to-use. Intended for in vitro diagnostic (IVD) use. MSH6 is a gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). HNPCC is reported to be the most common form of inherited Colorectal Cancer in the western world. MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). The anti-MSH6 antibody is useful in screening patients and families for HNPCC. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite-stable counterparts. References 1. Miyaki M, Konishi M, Tanaka K, et al. Nat Genet. 1997; 17(3): 271-2 2. Yin J, Kong D, Wang S et al. Hum Mutat. 1998; 10(6): 474-8 3. Guerrette S, Wilson T, Gradia S, Fishel R, Mol Cell Biol. 1998; 18(11):6616-23 4. Winjnen j, deLeeuw W, Vasen H, et al. Nat. Genet. 1999, 23(2): 142-4 5. Wu Y, Berends MJ, Mensink RG, et al. Am J Hum Genet. 1999;65(5)1291-9 6. U.S. 29CFR 1910.1200, OSHA Hazard Communication and EC Directive 91/155/EC.