Description
Mouse Monoclonal. Intended for in vitro diagnostic (IVD) use. MLH-1 is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumors that are microsatellite unstable. References 1. Pat T, et al. Cancer. 2008; 113-733-42 2. Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-406. 3. Bruecki WM, et al Anticancer Res. 2003:23:1773-8 4. Rigau V, et al. Arch Pathol Lab Med. 2003: 127-694-700. 5. Renkonen E, et al. J. Clin Oncol. 2003; 21-3629-37 6. Hoedema R, et al. Am Surg 2003: 69-387-92 7. Christensen M, et al. Cancer 2002, 95:2422-30
Storage
Refrigerated Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F)
Refrigerated storage upon delivery is important for correct product functionality.
