Mouse Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. Vimentin is a member of the intermediate filament family of proteins. Expression of vimentin, when used in conjunction with keratin, is helpful in distinguishing melanomas from undifferentiated carcinomas and large-cell lymphomas. All melanomas and schwannomas react strongly with vimentin. This antibody recognizes a 57 kDa intermediate filament. It labels a variety of mesenchymal, including melanocytes, lymph cells, endothelial cells, and fibroblasts. Nonreactivity of vimentin antibody is often considered more useful than its presence, since there are a few tumors that do not contain vimentin. References 1. U.S. 29CFR 1910.1200, OSHA Hazard Communication and EC Directive 91/155/EC. 2. Center for Disease Control, 1976, National Institute of Occupational Safety and Health, 1976. 3. U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories, Supplement/Vol 61, January 6, 2012. 4. Kiernan, Microscopy Today 00-1 pp. 8-12, (2000) 5. Sheehan and Hrapchak, Theory and Practice of Histotechnology, Second Edition, Battelle Press, 1980 6. Nadji and Morales, AR Ann N.Y. Acad Sci 420:134-9, 1983 7. Omata M et al, Am J Clin Pathol 73(5): 626-32, 1980