Rabbit Monoclonal, IVD, RTU. Intended for in vitro diagnostic (IVD) use. PMS2 is a gene that encodes for DNA repair proteins involved in mismatch repair. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. Along with MLH1, MSH2 and MSH6, PMS2 is helpful in diagnosing MSI. Tumors with low-level MSI show unfavorable pathological characteristics compared to tumors with none and tumors with high-level MSI. References 1. Garg K, et al. J Clin Pathol. 2009: 62-679-684 2. Gill S, et al. Clin Cancer Res. 2005; 11:6466-71 3. Modica I, et al. Am J Surg Pathol. 2007; 31:744-51 4. Shia J, et al. Am J Surg Pathol. 2009; 1639-45 5. Kets CM, et al. Mod Pathol. 2006; 19:1624-30