Mouse Monoclonal. Intended for in vitro diagnostic (IVD) use. Anti-HMB45 is a useful melanoma immunohistochemical marker that reacts with antigens present on immature melanosomes. This antibody is useful for identifying amelanotic melanoma from other neoplastic lesions with similar morphology. References 1. Gown AM, et al. Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes. Am J Pathol. 1986; 123:195-203. 2. Wick MR, et al. Immunohistochemical diagnosis of sinonasal melanoma, carcinoma, and neuroblastoma with monoclonal antibodies HMB-45 and anti-synaptophysin. Arch Pathol Lab Med. 1988; 112:616-20. 3. Abrahamsen HN, et al. Sentinel lymph nodes in malignant melanoma: extended histopathologic evaluation improves diagnostic precision. Cancer. 2004; 100:1683-91. 4. Vaggelli L, et al. Radioisotopic lymphatic mapping of the sentinel node in melanoma:importance of immunohistochemistry. Tumori. 2000; 86:346-8. 5. Baisden BL, et al. HMB-45 immunohistochemical staining of sentinel lymph nodes: a specific method for enhancing detection of micrometastases in patients with melanoma. Am J Surg Pathol. 2000; 24:1140-6. "