Rabbit Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. SOX-10 is a transcription factor involved in neural crest and peripheral nervous system development and acts as a nucleocytoplasmic shuttle protein. Following migration, it remains expressed in cells destined for glial, schwannian, and melanocytic differentiation. SOX-10 is widely expressed in normal human tissues, including melanocytes and breast tissue. It is also an important marker in malignant tumors such as melanomas and breast carcinomas of basal-like and triple negative type, gliomas, and benign tumors such as schwannomas. References 1. Nonaka D, et al.: Am J Surg Pathol 2008, 32: 1291-1298 2. Mohamed A, et al.:Appl Immunohistochem Mol Morphol 2012 3. Cimino-Mathews A, et al.: Hum Pathol 2013, 44:959-965 4. Ivanov SV, et al.: Br J Cancer 2013, 109:444-451